DERE Kwadjo Anicet Luc
Laboratory of clinical biochemistry of Bouake medical school, Cote d’IvoirePresentation Title:
Biochemical profile of patients in ketosis-prone diabetes state in Côte d’Ivoire.
Abstract
Introduction: Diabetes keto-acidosis (DKA) is the most serious hyperglycemic emergency in patients with diabetes. DKA has long been considered a key clinical feature of T1D, an auto-immune disorder characterized by severe and irreversible insulin deficiency. In this study, we tried to assess biochemical disorders based on lipid and renal parameters at the moment of diagnosis. Methodology: We carried out a case-controls study for approximately one year, from December 2020 to September 2021. We have got 100 participants in ketosis-prone diabetes state and 100 non-diabetic participants. Patients were outpatients newly diagnosed diabetics attending, for the first time, one of the three different hospitals designated to implement this study (Bouaké). We registered demographic and antrhopometric informations through questionnaire. Blood samples were taken, after 10 to 12 hours of fasting from the day before, in different tubes for each intended analyses according to instructor’s recommendation. Results: we reported that the increased mean value of fasting blood glucose together with HbA1c are corrolated with ketonuria. With regard to cardio-metabolic risk, ketosis-prone patients were at greater risk than non-ketosis-dependent controls, both in terms of atherogenic index and consequently in cardio-metabolic risk, which increased with the degree of ketonuria. The mean AIP value was higher in women than in men, with no significant statistical correlation even with the other socio-demographic indicators. Uremia and creatininemia, were correlated with some social indicators. The mean values of these both parameters increased with age in both participants. Creatinine increasing was statistically significant with age for patients, in line with glomerular filtration rate (GFR). Overall, age had a negative influence on the glomerular filtration parameters such as urea and creatinine. The older the participants, the higher the mean values of these parameters. Conclusion: These biochemical indicators, high atherogenic index and lower glomerular filtration rate, documented in our study, have to be sought out when inaugural ketosis is suspected for improving the clinical prognosis of patients in the initial step of management.
Key words: ketonuria, ketosis-prone diabetes, biochemical profile.
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