Background: Type 2 diabetes mellitus is a public health problem whose severity and prognosis depend on the long-term onset of various chronic complications such as diabetic nephropathy, which requires assessment of renal function by estimating GFR (glomerular filtration rate). Several formulas have been proposed. The EKFC equation, obtained by combining the FAS ( full age spectrum ) and CKD-EPI equations, has been proposed as a more universal formula for estimating glomerular filtration rate. It has the advantage of eliminating racial correction and covering a wide age range. The aim of this study is to compare the EKFC (2021) and CKD-EPI 2021 equations for estimating glomerular filtration rate (eGFR) in an Algerian population with type 2 diabetes.

Materials and Methods: This is an observational, cross-sectional, analytic study. Creatinine levels were measured using the Cobas Integra 400 Roche diagnostic device, and the results were used to estimate GFR using the two formulas: CKD-EPI 2021 and EKFC.

Results: There is a statistically significant difference between the performance of the CKD-EPI (2021) and EKFC equations (p< 0.001), but a very good correlation (r=0.99) despite the fact that the EKFC underestimates eGFR compared to CKD-EPI 2021 (bias is -8 ml/min/1.73). Conclusion: The main value of the EKFC lies in its ability to provide a detailed stratification of the early stages of kidney disease. Our study also represents the first attempt to establish the Q-value in the Algerian population; further studies are recommended.

Zohra Sedoud is an Algerian biomedical researcher and academic affiliated with the Faculty of Pharmacy, University of Algiers 1, and the Biochemistry Laboratory at Rouiba Hospital. Her research interests include clinical biochemistry, metabolic disorders, glycemic control, laboratory diagnostics, and biochemical markers. She has contributed to research on haemoglobinopathies, diabetes-related biomarkers, renal and metabolic disorders, and cancer biomarkers, with a focus on improving clinical laboratory assessment and patient care.